The Comprehensive Adrenal Stress Profile comprises of the standard Adrenal Stress Profile (which assesses cortisol and DHEA levels) and Secretory IgA (SIgA). Imbalances of cortisol, DHEA and SIgA can lead to the most common health complaints of the 21st century. Both excesses and deficiencies of DHEA and cortisol have been implicated in the aetiology of various illnesses and immune suppression.